Biological evaluation of Acacia nilotica (L.) Willd. ex Delile: a systematic review

Acacia nilotica is a popular medicinal plant that grows all throughout Africa, the Middle East, and the Indian subcontinent. This is because the plant, from its roots to its leaves, contains a wide variety of compounds that have been utilized for ages in traditional medicine. To glean useful information, online databases like Science Direct, PubMed, Wiley, Springer, Sage, Google Scholar, and Hindawi combed through actual scientific research papers. requisites for inclusion We used terms like "A. nilotica," "A. nilotica antioxidant," "conventional medicine," "antidiabetic," "antibacterial," "medicine," "toxicity," "antiviral," and "antimicrobial," as well as any other relevant terms as our search criteria. Exclusion standards: No information from dubious online sources was used in our investigation. Thesis papers, review articles, and articles written in languages other than English were also not included. Unquestionably, the results of this study will be helpful in evaluating the efficacy of the crude extracts of A. nilotica components as potential sources of natural antioxidants, antimicrobials, antiparasites, antidiabetic, and anticancer agents. However, more study is needed to identify the precise chemical responsible for the biological activity and advance to clinical trials before application in the pharmaceutical industry. Despite all promising research that has been done so far, there is still a lack of data, particularly from clinical investigations, that supports the adjunct use of A. nilotica. This promotes more preclinical and clinical investigations into A. nilotica.

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Abbreviations

Total antioxidant capacity, reducing power

Lipid peroxidation by thiobarbituric acid assay

Colony forming units

2, 20-Diphenyl-1-picrylhydrazyl radical

Polymerase chain reaction

Egg hatch inhibition assay

Larvae exsheathment inhibition assay using Haemonchus contortus as a model

Adult mortality test

Total antioxidant activity

β-Carotene bleaching assay

Trolox equivalent antioxidant capacity

Red blood cells

White blood cells

Packed cell volume

Inhibition of damage to DNA methods

Median lethal dose

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